Synthesis, characterization, in vitro degradation and cytotoxicity of poly[bis(ethyl 4-aminobutyro)phosphazene]

✍ Scribed by Menemşe Gümüşderelioǧlu; Altuǧ Gür

• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Weight: 885 KB
• Volume: 52
• Category: Article
• ISSN: 1381-5148
• DOI: 10.1016/s1381-5148(02)00081-0

✦ Synopsis

The synthesis and characterization of degradable poly[bis(ethyl 4-aminobutyro)phosphazene] is described. This polymer was prepared by a two-step reaction procedure. First, poly(dichlorophosphazene) was synthesized by thermal polymerization of the cyclic trimer hexachlorocyclotriphosphazene. In the second stage, the poly(dichlorophosphazene) structure was converted into the amino acid ethyl ester derivative by a nucleophilic substitution reaction. Both polymeric structures were 31 characterized by FTIR, P NMR, SEM and viscosity measurements. Degradation studies were carried out with 100 mm polymeric films in phosphate buffered saline at 37 8C. Mass loss measurements showed that, on day 25, 70% of the original mass was lost. In addition, non-toxic behavior of the polyphosphazene films was shown by cytotoxicity tests conducted in cell culture media.