Synthesis, characterization, antimicrobial, SOD mimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives

✍ Scribed by Mohan Patel; Deepen Gandhi; Pradhuman Parmar

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 278 KB
• Volume: 25
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.1766

✦ Synopsis

Square pyramidal copper(II) complexes with second-generation fluoroquinolone, pefloxacin and phenanthroline derivatives were prepared and characterized. They were also screened for in-vitro activity against two Gram (+ve) and three Gram (-ve) microorganisms. SOD mimic behavior was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT-NADH-PMS), and was found to have good antioxidant activity. The complexes are avid DNA binders having binding constant (K b ) in the power of 4. Viscosity measurement data confirmed that complexes bind through classical intercalative mode of binding. The cleavage ability on pUC19 DNA was determined using gel electrophoresis technique.