Synthesis, characterization, and in vitro degradation of star-shaped P(ε-caprolactone)-b-poly(L-lactide)-b-poly(D,L-lactide-co-glycolide) from hexakis [p-(hydroxymethyl)phenoxy]cyclotriphosphazene initiator
✍ Scribed by Weizhong Yuan; Jinying Yuan; Xiaobin Huang; Xiaozhen Tang
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 190 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Abstract
Hexaarmed star‐shaped hydroxyl‐terminated poly(ε‐caprolactone) (PCL) was successfully synthesized via the ring‐opening polymerization of ε‐caprolactone (CL) with hexakis[p‐(hydroxymethyl)phenoxy]cyclotriphosphazene initiator and stannous octoate catalyst in bulk. The star‐shaped PCL with hydroxy end groups could be used as a macroinitiator for block copolymerization with L‐lactide (L‐LA). The star‐shaped triblock copolymer was synthesized by above‐mentioned hydroxyl‐terminated star‐shaped diblock PCL‐b‐PLLA, D,L‐lactide (D,L‐LA), and glycolide (GA). IR, ^1^H NMR, and GPC analysis showed that the star‐shaped block copolymers were successfully synthesized and the molecular weights and the unit composition of the star‐shaped block copolymers were controlled by the molar ratios of monomer to initiator. The triblock copolymer presented a three‐phase structure, namely, PCL crystalline, PLLA crystalline, and D,L‐PLAGA amorphous domains, which made the triblock copolymer different from the diblock copolymer and star‐shaped PCL in crystallizability and thermal behaviors. Then, the in vitro degradation behaviors of the copolymers were investigated. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 2310–2317, 2007