Synthesis, characterization and evaluation of novel methoxypolyethyleneglycol- grafted- poly(ester-urethane)s for controlled release of repaglinide

✍ Scribed by S. Vijay Kumar; Namdev B. Shelke; S. Prasannakumar; Ajit P. Rokhade; B. S. Sherigara; Tejraj M. Aminabhavi

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 410 KB
• Volume: 113
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.29497

✦ Synopsis

Abstract

Novel biodegradable aliphatic poly(ester‐urethane)s (PEUs) based on polycaprolactone diol (PCL) and methoxypolyethyleneglycol grafted onto trimethylol propane (mPEG‐g‐TMP) were synthesized by solution polymerization technique and characterized using a variety of techniques. Microspheres ranging in size from 7 to 25 μm were prepared by the solvent evaporation technique and loaded with repaglinide up to 71 to 96%. Increasing molar ratios of mPEG‐g‐TMP propane with respect to polycaprolactone diol gave increase in particle size along with increase in % encapsulation efficiency. Surface morphology and spherical nature of the microspheres were confirmed by scanning electron microscopy (SEM). The release of repaglinide varied, depending upon the molar ratios of mPEG‐g‐TMP moieties with respect to PCL. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009