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Synthesis, Characterization and Cytotoxicity of Diam(m)-ineplatinum(II) Complexes Containing β-phenylisosuccinate Ligand

✍ Scribed by Qing-Song Ye; Li-Guang Lou; Zuo-Yan Liu; Wei-Ping Liu; Shu-Qian Hou; Xi-Zhu Chen; Yao Yu

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 371 KB
Volume: 340
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200700114

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✦ Synopsis

Abstract

Four diam(m)ineplatinum(II) complexes containing β‐phenylisosuccinate as the leaving groups were prepared, characterized, and evaluated for their cytotoxicity against A549/ATCC human lung cancer cell line and SGC‐7901 human gastric cancer cell line. One of the complexes, (__trans‐__1__R,__2__R‐__diaminocyclohexane)‐β‐phenylisosuccinatoplatinum(II) 4, was much more active than cisplatin and carboplatin.

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