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Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]-oxadiazoles with fluorobenzimidazoles

✍ Scribed by Ganesh R. Jadhav; Mohammad U. Shaikh; Rajesh P. Kale; Anand R. Ghawalkar; Charansingh H. Gill

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
115 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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In this study, a novel series of substituted 4,6‐difluoro‐2‐{2‐[3‐(substituted‐phenyl)‐[1,2,4]‐oxadiazol‐5‐yl]‐ethyl}‐1__H__‐benzo[d]imidazole derivatives were synthesized by condensation of 2,4‐difluoro 6‐nitrophenyl amine with 3‐(substitutedphenyl‐[1,2,4]‐oxadiazol‐5yl) propionic acid by using 2,4,6‐trichlorobenzoyl chloride in the presence of triethyl amine base. The compounds were evaluated for their preliminary in vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa. The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed moderate activity with reference standard Gentamycin. J. Heterocyclic Chem., (2009).

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