Synthesis, characterization, and anti-inflammatory evaluation of 1,2,4-oxadiazoles combined with thiosemicarbazide and 1,3,4-oxadiazole moieties

✍ Scribed by José M. dos Santos Filho; José G. de Lima; Lúcia F. C. C. Leite

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 100 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.133

✦ Synopsis

Abstract

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The reaction of 1,2,4‐oxadiazole carbohydrazides 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h with phenyl isothiocyanate led to an unexpected ring cyclisation of the thiosemicarbazide derivatives 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, giving compounds 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h as side products. These two new series were preliminarily evaluated for their anti‐inflammatory activity, using the carrageenin induced edema protocol. J. Heterocyclic Chem., (2009).