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Synthesis, Biological Evaluation, and Three-Dimensional Quantitative Structure−Activity Relationship Study of Small-Molecule Positive Modulators of Adrenomedullin

✍ Scribed by García, Mario A.; Martín-Santamaría, Sonsoles; Cacho, Mónica; Moreno de la Llave, Fernando; Julián, Miguel; Martínez, Alfredo; de Pascual-Teresa, Beatriz; Ramos, Ana

Book ID: 121292379
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 340 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm050021+

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## Abstract The three‐dimensional quantitative structure‐activity relationships of a series of 5‐[1‐aryl‐1,4‐dihydro‐6‐methylpyridazin‐4‐one‐3‐yl]‐2‐arylamino‐1,3,4‐thiadiazoles, related to the fungicidal activity, were studied using the comparative molecular field analysis (CoMFA). The results sho