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Synthesis, biological evaluation, and molecular modeling studies of new 1,3,4-oxadiazole- and 1,3,4-thiadiazole-substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines as anti-HIV-1 agents

✍ Scribed by Hajimahdi, Z.; Zarghi, A.; Zabihollahi, R.; Aghasadeghi, M. R.

Book ID: 118277394
Publisher: Springer-Verlag
Year: 2012
Tongue: English
Weight: 427 KB
Volume: 22
Category: Article
ISSN: 1054-2523
DOI: 10.1007/s00044-012-0241-5

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## Abstract 5‐substituted 4‐(4‐chlorophenyl)‐4H‐1,2,4‐triazol‐3‐thiones **3** and 2‐substituted 5‐(4‐chlorophenylamino)‐1,3,4‐thiadiazoles **4** were prepared from the intermediate thiosemicarbazides **2** under basic and acidic conditions, respectively. The thiosemicarbazides, in turn, were prepar