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Synthesis andin VitroStudy of a Diglyceride Prodrug of a Peptide

✍ Scribed by Florence Delie; Patrick Couvreur; Dino Nisato; Jean-Baptiste Michel; Francis Puisieux; Yves Letourneux

Book ID
110379470
Publisher
Springer US
Year
1994
Tongue
English
Weight
916 KB
Volume
11
Category
Article
ISSN
0724-8741

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πŸ“œ SIMILAR VOLUMES

Phase behaviour of a diglyceride prodrug
Phase behaviour of a diglyceride prodrug: Spontaneous formation of unilamellar vesicles
✍ S. Mantelli; P. Speiser; H. Hauser πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 English βš– 923 KB

A prodrug (Fig. 1(IV)) is synthesized consisting of the beta-blocker bupranolol which is covalently linked to 1, 3-dipalmitoyl-2-succinyl-glycerol. The resulting lipid-like prodrug is amphipathic and surface active. It disperses readily in H2O above 30 degrees C forming a smectic lamellar phase. Thi

Synthesis and aqueous organization of 1,
Synthesis and aqueous organization of 1,3-dipalmitoyl-2-(4-aminobutyryl) glycerolΒ·HCl: a diglyceride prodrug
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1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol β€’ HCI, a diglyceride ester of 7-aminobutyric acid (GABA), was synthesized with a good yield (46.5%). This prodrug ( 1,3-dp-GABA " HCI) was highly amphiphilic and formed stable dispersions in water. The thermodynamic parameters of the endothermic transition