Synthesis and α-glucosidase inhibitory, DPPH scavenging activity of substituted 2-oxo-2H-chromen-7-yl-dihydrogen phosphate derivatives

✍ Scribed by J. Ashok Kumar; Ashok K. Tiwari; A.Zehra Ali; R. Ranga Rao; B. China Raju

• Book ID: 102344203
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 234 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.675

✦ Synopsis

Abstract

Series of phosphorylated coumarin derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j) were synthesized by Pechmann condensation, phosphorylation, and debenzylation reactions in very good yields. Thus, synthesized compounds (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j) were evaluated for their α‐glucosidase and 1,1‐diphenyl‐2‐picrylhydrazyl scavenging activities; few compounds showed moderate to good activity. J. Heterocyclic Chem., 00, 00 (2011).