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Synthesis and Use of 2H-Azirin-3-amines as Dipeptide Synthons

✍ Scribed by Roland A. Breitenmoser; Heinz Heimgartner


Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
333 KB
Volume
85
Category
Article
ISSN
0018-019X

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📜 SIMILAR VOLUMES


A Novel 2H-Azirin-3-amine as a Dipeptide
✍ Roland A. Breitenmoser; Thomas R. Hirt; Roeland T. N. Luykx; Heinz Heimgartner 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 German ⚖ 104 KB 👁 1 views

The synthesis of methyl (2S,4R)-4-(benzyloxy)-N-(2,2-dimethyl-2H-azirin-3-yl)prolinate ( 10), a novel 2Hazirin-3-amine (3-amino-2H-azirine), is described (Scheme 1). The reaction of methyl (2S,4R)-N-(2methylpropanoyl)-4-(benzyloxy)prolinate ( 7) with Lawesson reagent gave methyl (2S,4R)-4-(benzyloxy

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The physical and spectroscopic data found for the products (2) are identical with those found by earlier workersrl.21.