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Synthesis and transport applications of 3-aminobicyclo[3,2,1]octane-3-carboxylic acids

✍ Scribed by Christensen, Halvor N.; Handlogten, Mary E.; Vadgama, Jaydutt V.; De la Cuesta, Elena; Ballesteros, Paloma; Trigo, Gregorio G.; Avendano, Carmen


Book ID
127043082
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
746 KB
Volume
26
Category
Article
ISSN
0022-2623

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8-Aminobicyclo[3.2.1]octanes: synthesis
✍ J.A Miller; G.M Ullah; G.M Welsh; A.C Hall πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 165 KB

A series of 8-chlorobicyclo[3.2.1]oct-6-enes has been prepared from cyclohexenyl chlorides and simple alkynes via a one-step [3+2] cycloaddition methodology, and then converted into the corresponding bicyclic amines. Against influenza-A virus a number of these showed in vitro activity, and amine (2)