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Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3′-C-Ethynyl-3′-O,4′-C-methyleneribonucleotides

✍ Scribed by Patrick J. Hrdlicka; T. Santhosh Kumar; Jesper Wengel

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 108 KB
Volume: 2005
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200500379

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✦ Synopsis

Abstract

Incorporation of conformationally restricted 3′‐C‐ethynyl‐3′‐O,4′‐C‐methyleneribonucleotide X monomers into oligodeoxyribonucleotides results in large decreases in affinity towards complementary DNA, whereas significantly more stable duplexes are formed with RNA complements. RNA selectivity becomes more pronounced upon multiple incorporations of X monomers. Increased thermal stability is observed upon positioning of two X monomers in a +1 zipper interstrand motif. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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