Synthesis and testing of novel phenyl substituted side-Chain analogues of classical cannabinoids

✍ Scribed by Mathangi Krishnamurthy; Antonio M. Ferreira; Bob M. Moore II

• Book ID: 104364047
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 144 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00729-7

✦ Synopsis

A series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their CB1 and CB2 binding affinities were evaluated relative to Á 8 -THC and compound 2. CB1 and CB2 binding assays indicate that the dimethyl and ketone analogues (3) and ( 6) display selectivity for the CB2 receptor in comparison to Á 8 -THC and compound 2. This study provides newer insights into the geometrical and functional group requirements of the ligand binding pockets of the CB1 and the CB2 receptors.