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Synthesis and swelling properties of novel pH-sensitive poly(aspartic acid) gels

✍ Scribed by Tamás Gyenes; Viktória Torma; Benjámin Gyarmati; Miklós Zrínyi

Book ID
103999442
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
968 KB
Volume
4
Category
Article
ISSN
1742-7061

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✦ Synopsis

Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory.

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