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Synthesis and Structure−Activity Relationships of N -{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors.

✍ Scribed by Gu, Yu Gui; Weitzberg, Moshe; Clark, Richard F.; Xu, Xiangdong; Li, Qun; Zhang, Tianyuan; Hansen, T. Matthew; Liu, Gang; Xin, Zhili; Wang, Xiaojun; Wang, Rongqi; McNally, Teresa; Zinker, Bradley A.; Frevert, Ernst U.; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.


Book ID
126262512
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
7 KB
Volume
49
Category
Article
ISSN
0022-2623

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A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modification of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic profile in rat are described.