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Synthesis and Structure–Activity Relationships of Constrained Heterocyclic Analogues of Combretastatin A4

✍ Scribed by Dr. Martin Arthuis; Dr. Renée Pontikis; Dr. Guy G. Chabot; Johanne Seguin; Lionel Quentin; Dr. Stéphane Bourg; Dr. Luc Morin-Allory; Dr. Jean-Claude Florent


Book ID
102805518
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
853 KB
Volume
6
Category
Article
ISSN
1860-7179

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Synthesis and cytotoxic evaluation of ci
✍ Magali Lorion; Vangelis Agouridas; Axel Couture; Eric Deniau; Pierre Grandclaudo 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 460 KB

A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.