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Synthesis and Structure–Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A 1

✍ Scribed by Cochrane, Stephen A.; Lohans, Christopher T.; Brandelli, Jeremy R.; Mulvey, George; Armstrong, Glen D.; Vederas, John C.


Book ID
126865566
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
523 KB
Volume
57
Category
Article
ISSN
0022-2623

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Peptide YY (PYY) not only has distinct sequence homology with neuropeptide Y (NPY) and avian pancreatic polypeptide (APP), but i t also exhibits both NPY-and APP-like biological activities. We synthesized two analogues of PYY, A1 and A2, with modified N-terminal regions, and compared their chemical