Synthesis and Structure of New Pyrido[2,3-d]pyrimidine Derivatives with Calcium Channel Antagonist Activity

✍ Scribed by Alfredo Pastor; Ramón Alajarin; Juan J. Vaquero; Julio Alvarez-Builla; Miguel Fau de Casa-Juana; Carlos Sunkel; Jaime G. Priego; Isabel Fonseca; Julia Sanz-Aparicio

• Book ID: 104203219
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 921 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)85291-1

✦ Synopsis

Several series of pyrido[2,3d]pyrimidi derivatives were synthesized by reaction of arylmethyleneacetoacetates with different arninopyrimidines. 'Ihe solid-state structure of the methyl 5-(3'chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2.3,4JB-hexahy~do[~d]~~e~~~xy~~ shows that these compounds can adopt some of the most important structural features of the 1,4dihydropyridine calcium channel blockers. The scope and lbnitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compouad nifedipine.

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