Synthesis and Structure of (Carboxymethyl)-Functionalized Cyclobuta-Fused uracil dimers

✍ Scribed by Thomas Carell; Robert Epple; Volker Gramlich

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: German
• Weight: 767 KB
• Volume: 80
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19970800718

✦ Synopsis

Abstract

Herein, we report a convenient method for the preparation of four benzyl‐ester‐protected, (carboxymethyl)‐functionalized cyclobuta‐fused uracil dimers 1–4, including the desired cis‐cisoid‐cis,syn‐ configured isomer 1, a compound which is suitable for the preparation of catalytic antibodies, synthetic receptors, and model compounds, required for the investigation of the DNA‐lesion, recognition step and DNA‐repair mechanisms. A comprehensive structure determination of each isomer by ^1^H‐NMR, and in the case of the cis‐cisoid‐cis,syn‐ and the __cis‐traftsoid‐cis,Syn‐__dimers by X‐ray crystal‐structure analysis, is also provided.