Synthesis and biological activity of 5-[
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Tianming Liu; Ryuichi Shirai; Takashi Matsui; Kazuo Umezawa; Shigeo Iwasaki
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Article
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1997
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Elsevier Science
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English
โ 181 KB
The synthesis and biological activity of a series of 5-[(2,5dihydroxybenzyl)amino]salicylic acid derivatives (3-6) as analogs of the active partial structure (2) of the potent EGF-R tyrosine kinase inhibitor lavendustin A (1) are described. Analogs with an electron-withdrawing group in place of the