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Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity

โœ Scribed by Chen, Huixiong; Boiziau, Janine; Parker, Fabienne; Maroun, Rachid; Tocque, Bruno; Roques, Bernard P.; Garbay-Jaureguiberry, Christiane


Book ID
124091683
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
660 KB
Volume
36
Category
Article
ISSN
0022-2623

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The synthesis and biological activity of a series of 5-[(2,5dihydroxybenzyl)amino]salicylic acid derivatives (3-6) as analogs of the active partial structure (2) of the potent EGF-R tyrosine kinase inhibitor lavendustin A (1) are described. Analogs with an electron-withdrawing group in place of the