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Synthesis and Structure-Activity Relationships of Juvenoids Derived from 2-(4-hydroxybenzyl)cycloalkan-1-ones

✍ Scribed by Martin Rejzek; ZdenêK Wimmer; David Šaman; Michaela Říčánková; Václav Nêmec

Publisher
John Wiley and Sons
Year
1994
Tongue
German
Weight
967 KB
Volume
77
Category
Article
ISSN
0018-019X

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✦ Synopsis

Juvenoids 1&30,32,36,3841, 44-46, and 49-56 containing carbamate, carbonate, and urea moieties in the molecule were synthesized and subjected to a biological screening (Schemes 2-7, Table 2). Carbamate juvenoids 1 4 were used as reference compounds for a detailed structure-activity study of their analogues. A clear relationship between the nature of the side chain functional group and the biological activity was found. Surprisingly, not only the juvenoids 1 4 but also 3841, the compounds with a reversed carabamate N,U-substitution pattern, showed very promising biological activity. In contrast, the carbonate and urea derivatives displayed a remarkably low activity. The relationship between the size and substitution at atoms C(2) and C(3) of the saturated ring and the biological activity is very complex and is still not completely understood.

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