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Synthesis and Structure-Activity Relationship of Di-(3, 8-diazabicyclo[3.2.1]octane) Diquaternary Ammonium Salts as Unique Analgesics

โœ Scribed by Hong Liu; Tie-Ming Cheng; Hong-Mei Zhang; Run-Tao Li


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
73 KB
Volume
336
Category
Article
ISSN
0365-6233

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Trimethylpiperazines as Monocyclic Analogues of the . mu.-Opioid Agonist 3,8-Diazabicyclo(3.2.1)octanes: Synthesis, Modeling, and Activity. -The trimethylpiperazine derivatives (IV)-(VII) are tested in binding studies for ยต-opioid receptors. Their different affinity towards . mu.-opioid receptors i