## Abstract A simple and convenient synthesis of a radiolabeled antihypertensive pyridazinone was developed. The product was purified chromatographically, and the chemical and radiochemical purities of the sample were determined.
Synthesis and structure-activity analysis of 2-(4-chlorophenyl)-5,6-dihydrothieno[2′,3′:2,3]thiepino[4,5-c]pyridazin-3(2H)-ones as ligands for benzodiazepine receptors
✍ Scribed by H Tanaka; S Kirihara; H Yasumatsu; T Yakushiji; T Nakao
- Book ID
- 103630113
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 905 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0223-5234
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## Abstract The isomeric compounds 5,6‐dihydrothieno[2,3‐__h__]cinnolin‐3(2__H__)‐one (7a) and 5,6‐dihydrothieno‐[3,2‐__h__]cinnolin‐3(2__H__)‐one (7b) rapidly tautomerise to the corresponding 1,4‐dihydrothienocinnolinones 8a,b when kept in refluxing hydrazine hydrate. With longer reaction times th
## Abstract Derivatives **7**–**13** of a new tricyclic heteroaromatic system, pyrido[3′,2′:5,6]thiopyrano[4,3‐__c__]pyridazin‐3(2__H__,5__H__)‐one, were prepared as potential ligands at the benzodiazepine receptor, in view of their structural analogy with potent ligands such as the pyrazoloquinoli