## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and structural investigation of some pyrimido[5,4-c]quinolin-4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT1A/2A and 5-HT7 receptor ligands
✍ Scribed by Wieslawa Lewgowd; Andrzej J. Bojarski; Malgorzata Szczesio; Andrzej Olczak; Marek L. Glowka; Stefan Mordalski; Andrzej Stanczak
- Book ID
- 108116613
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 624 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0223-5234
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## Abstract As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5‐__c__]quinoline‐1(2__H__)‐one ring skeleton, we were interested in identifying structural elements that contribute to the cytotoxicity of this class of compounds. The eff
## Abstract 4‐[3‐[4‐(2‐Methoxyphenyl)piperazin‐1‐yl]propoxy]‐4‐aza‐tricyclo[5.2.1.02,6]dec‐8‐ene‐3,5‐dione (4), a potent and selective 5‐HT~1A~ agonist, was labeled by ^11^C‐methylation of the corresponding desmethyl analogue 3 with ^11^C‐methyl triflate. The precursor molecule 3 was synthesized fr