Synthesis and structural characterization of 6I,6II-diamino-6I,6II-dideoxy-cyclomaltoheptaose, a difunctionalized β-cyclodextrin

✍ Scribed by Benedetto Di Blasio; Stefania Galdiero; Michele Saviano; Carlo Pedone; Ettore Benedetti; Enrico Rizzarelli; Sonia Pedotti; Graziella Vecchio; William A. Gibbons

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 652 KB
• Volume: 282
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(95)00357-6

✦ Synopsis

61,6tLDiamino-6~,6U-dideoxy-cyclomaltoheptaose was prepared using the regioselective procedure described by Tabushi. The difunctionalized fl-cyclodextrin crystallizes as hexadecahydrate in the orthorhombic space group P2~2121, with a = 11.395(3), b = 32.989(9), c = 17.560(5) ,~, V= 6601 43, Z= 4. The structure was solved by molecular replacement techniques using the program PATSEE and was refined to a conventional final R = 0.058 for the 5031 observed reflections with I > 3o'(1). The fl-CD macrocycle presents only slight differences with respect to uncomplexed hydrated or methylated fl-CD. The macrocycle structure maintains an approximate * Corresponding author. i Crystallographic data deposited with the Cambridge Crystallographic Data Centre. These data may be obtained, on request, from the Director,