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Synthesis and stereostructure of some 5,5′-disubstituted 3-acetyl-2,2′-BI-2H-1,3,4-oxa(thia)diazolines

✍ Scribed by László Somogyi; Mátyás Czugler; Pál Sohár


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
701 KB
Volume
48
Category
Article
ISSN
0040-4020

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✦ Synopsis


The synrhesis of some (methyf)glyoxal 1,2-bis(cxylhydrazones) (1,3-6) and their cyclization into the title compounds (7-10) under acetylating conditions p-e descriged. The stereostructures of the new bi-heterocyclic diastcrcomers were studied by H-and I C-NMR measurements as well as by X-ray anulysis.


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Synthesis and stereostructure of some sp
✍ Somogyi, László ;Szabó, Zoltán ;Hosztafi, Sándor 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB

## Abstract Treatment of dihydrocodeinone (thio)semicarbazones 1a–d with Ac~2~O/ZnCl~2~ afforded (6__S__)‐spiro[morphinan‐6,2′(3′__H__)‐[1,3,4]oxadiazolines] (2a, b) and (6__R__)‐spiro[morphinan‐6,2′‐(3′__H__)‐[1,3,4]thiadiazolines] (3a, b), respectively. The structure of the products including the