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Synthesis and stereochemical assignment of 2,5-trans-2′,5′-trans-5,5′-dimethylperhydro-2,2′-bipyrimidine and heterocycles derived from its condensation with formaldehyde

✍ Scribed by Michael Kassiou; Roger W. Read


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
680 KB
Volume
50
Category
Article
ISSN
0040-4020

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A 7-step synthesis of (\*)-trans-2-butyl-5-heptylpyrrolidine (14) from the Lukes-Sorm dilactam 1 was accomplished in 6 % overall yield without counting for a reconversion of cis-isomer 13 into trans-isomer 14 which was also accomplished. Reduction of pyrroline 12, the precursor of 14, with NaBH, aff