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Synthesis and specific pressor activity of [1-aspartic acid, 5-valine, 9-serine]angiotensin I ("fowl and angiotensin I")

โœ Scribed by Khosla, M. C.; Bumpus, F. M.; Hayashi, Y.; Nakajima, T.; Watanabe, T. X.; Sokabe, H.


Book ID
127287121
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
267 KB
Volume
20
Category
Article
ISSN
0022-2623

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We describe herein the synthesis of polybromodiphenylacetic acid (&), a fragment common to the tritiation substrates (a) and (JJ) of the sodium channel blocker, PD-85639 (1) and the angiotensin II inhibitor EXP-655 (2) respectively. Preparation of (a) and (11) followed by reductive debromonation wit