Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (IR,2R)-and (1S,2R)-2,3-O-cyclohexylidene-l,2,3trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightly impr
Synthesis and resolution of diethyl (1S,2S)-1-amino-2-vinylcyclopropane-1-phosphonate for HCV NS3 protease inhibitors
β Scribed by Hyung-Jung Pyun; Kleem Chaudhary; John R. Somoza; X. Christopher Sheng; Choung U. Kim
- Book ID
- 108285549
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 291 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract (R)β(β) Benzoin oxime **2** was catalytically tritiated to afford [2β^3^H] (1R,2S)β(β)β2βaminoβ1,2βdiphenylethanol **1** in 92% ee. Copyright Β© 2001 John Wiley & Sons, Ltd.
A concise synthesis and determination of absolute stereochemistry of two novel diastereomeric cyclopropyl containing transition state mimics isdescribed. A major advance in the development of renin inhibitors was the replacement of the scissile bond (PI-PI') with "transition state mimics" such as st
Title compound lb ('rity > 99%, 99.6% ee) is syrrthesized (IOOg scale) from commercial 3-bromo-pyruvic acid in six steps with on overall yield of 16% The sequence is operationally simple and devoid of chromatographic purijcations. Key step is the asymmetric hydmgenation of a substrate with sul/urjmc
## Abstract A convenient high yield synthesis of homochiral norpseudoephedrine starting from waste products of the chloramphenicol synthesis is described as an example of its utilization in chemical transformations.