Synthesis and relaxivity of polyamide paramagnetic metal complexes for magnetic resonance imaging

✍ Scribed by Ming Ouyang; Renxi Zhuo; Gongcheng Fu

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 274 KB
• Volume: 7
• Category: Article
• ISSN: 1042-7147
• DOI: 10.1002/(sici)1099-1581(199608)7:8<671::aid-pat557>3.0.co;2-9

✦ Synopsis

A new class of paramagnetic macromolecular magnetic resonance imaging contrast agents has been developed. Eight new polyamide ligands were synthesized by copolymerization of ethylenediaminetetraacetic acid dianhydride or diethylenetriarninepentaacetic acid dianhydride and diamine monomers. Their gadolinium(lIl), manganese(II) and iron(Il1) complexes were also synthesized. All polyamide ligands and metal complexes were characterized by lH nuclear magnetic resonance, infrared spectra and elemental analyses. Relaxivity studies showed that the polyamide paramagnetic metal complexes had obviously higher relaxation effectiveness as compared to corresponding simple monomeric paramagnetic metal complexes.