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Synthesis and regioselective alkylation of 1,6- and 1,7-naphthyridines

✍ Scribed by Vincent J Colandrea; Elizabeth M Naylor

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 115 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01400-3

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✦ Synopsis

A regioselective alkylation of naphthyridines 4a-d, through the action of ethylchloroformate and benzylstannane 5, afforded the benzyl substituted dihydronaphthyridines 3a-d. These key intermediates 3a-d were transformed into the desired targets 2a-d in seven steps.

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