✦ LIBER ✦

Synthesis and reactivity of benzothiazol-2-ylcarbonylhydroximoyl chloride, a versatile synthon

✍ Scribed by Ahmad M. Farag; Kamal M. Dawood; Abdou O. Abdelhamid

Book ID: 104208233
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 386 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)10194-6

No coin nor oath required. For personal study only.

✦ Synopsis

The versatile, hitherto unreported benzothiazol-2-ylcarbonylhydroximoyl chloride (2) was prepared by treatment of the corresponding sulfonium bromide 1 with sodium nitrite and hydrochloric acid in dioxane. Compound 2 reacts with o-aminothiopbenol and with o-phenylenediamine to afford the new ketones 3 and 4, respectively. Oxidation of the latter with lead tetraacetate gave the benzotriazine derivative 7. Reaction of 2 with heterocyclic amines furnished the novel fused heterocycles 8, 9, 12, 14 and 16. Compound 2 reacted also with 2-methyhhiobenzimidazole and gave the new heterocyclic system 18. Treatment of 2 with acrylonitrile, acrylamide and cx-(benzothiazol-2-yl)cinnamonitrile (25) in the presence of triethylamine afforded the isoxazole derivatives 21, 23 and 27, respectively.

📜 SIMILAR VOLUMES

Synthesis and reactivity of 3-(benzothia

Synthesis and reactivity of 3-(benzothiazol-2-yl)-3-oxopropanenitrile

✍ Ahmad M. Farag; Kamal M. Dawood; Zaghloul E. Kandeel 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 327 KB

2-Chloroquinazoline: Synthesis and React

2-Chloroquinazoline: Synthesis and Reactivity of a Versatile Heterocyclic Building Block.

✍ Signe Teuber Henriksen; Ulrik Svane Soerensen 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 26 KB

Synthesis and reactivity of 2-(benzothia

Synthesis and reactivity of 2-(benzothiazol-2-yl)-1-bromo-1,2-ethanedione-1-arylhydrazones

✍ Ahmad M. Farag; Kamal M. Dawood 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB 👁 1 views

The novel, highly versatile 2-(benzothiazol-2-yl)-1bromo-1,2-ethanedione-1-arylhydrazones 3 were prepared and their behavior toward some nucleophiles was investigated. Thus, reaction of 3 with the sodium salt of malononitrile afforded the aminopyrazolecarbonitriles 5 that undergo cyclocondensation w

ChemInform Abstract: Synthesis and React

ChemInform Abstract: Synthesis and Reactivity of 2-(Benzothiazol-2-yl)-1-bromo-1,2- ethanedione-1-arylhydrazones.

✍ A. M. FARAG; K. M. DAWOOD 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

Reactivity of 3-(benzothiazol-2-yl)-3-ox

Reactivity of 3-(benzothiazol-2-yl)-3-oxopropanenitrile: A facile synthesis of novel polysubstituted thiophenes

✍ M. A. Raslan; S. M. Sayed; M. A. Khalil; A. M. Farag 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 1 views

The reaction of 3-(benzothiazol-2-yl)-3oxopropanenitrile 1 with active methylene reagents 2a-d and sulfur afforded polysubstituted thiophenes 3a-c . The synthetic potential of the b-enaminonitrile moiety in 3a was explored. The reaction of 3a with active methylene reagents 2a-e afforded thieno [2,3b

ChemInform Abstract: Reactivity of 3-(Be

ChemInform Abstract: Reactivity of 3-(Benzothiazol-2-yl)-3-oxopropanenitrile: A Facile Synthesis of Novel Polysubstituted Thiophenes.

✍ M. A. Raslan; S. M. Sayed; M. A. Khalil; A. M. Farag 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views