Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide — a potential radiotracer for D3 receptor imaging with PET

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R.A. Dierck 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R. A. Dierc 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

Synthesis of 1-(2,4-dichlorophenyl)-4-cy

Synthesis of 1-(2,4-dichlorophenyl)-4-cyano-5-(4-[11C]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide ([11C]JHU75528) and 1-(2-bromophenyl)-4-cyano-5-(4-[11C]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide ([11C]JHU75575) as potential radioligands for PET imaging of cerebral cannabinoid receptor

✍ Hong Fan; Hayden T. Ravert; Daniel P. Holt; Robert F. Dannals; Andrew G. Horti 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 183 KB

## Abstract Two novel ligands for cerebral cannabinoid receptor (CB1), 1‐(2,4‐dichlorophenyl)‐4‐cyano‐5‐(4‐methoxyphenyl)‐__N__‐(piperidin‐1‐yl)‐1__H__‐pyrazole‐3‐carboxamide (JHU75528) and 1‐(2‐bromophenyl)‐4‐cyano‐5‐(4‐methoxyphenyl)‐__N__‐(piperidin‐1‐yl)‐1__H__‐pyrazole‐3‐carboxamide (JHU75575)

Synthesis, in vitro and in vivo evaluati

Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: A novel agonist 5-HT1A receptor PET ligand

✍ Jaya Prabhakaran; Ramin V. Parsey; Vattoly J. Majo; Shu-Chi Hsiung; Matthew S. M 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 200 KB

Synthesis of N-(piperidin-1-yl)-5-(4-met

Synthesis of N-(piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2-chlorophenyl)-4-[18F]fluoro-1H-pyrazole-3-carboxamide by nucleophilic [18F] fluorination: a PET radiotracer for studying CB1 cannabinoid receptors

✍ Reeti Katoch-Rouse; Andrew G. Horti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 91 KB

## Abstract The feasibility of nucleophilic displacement of bromide in the 4‐bromopyrazole ring with [^18^F]fluoride has been demonstrated by the synthesis of two radiolabeled compounds: __N__‐(piperidin‐1‐yl)‐5‐(4‐methoxyphenyl)‐1‐(2‐chlorophenyl)‐4‐[^18^F]fluoro‐1__H__‐pyrazole‐3‐carboxamide, ([^

Synthesis and preliminary in vivo evalua

Synthesis and preliminary in vivo evaluation of 4-[18F]fluoro-N-{2-[4-(6-trifluoromethylpyridin-2-yl)piperazin-1-yl]ethyl}benzamide, a potential PET radioligand for the 5-HT1A receptor

✍ M. Vandecapelle; F. Dumont; F. De Vos; K. Strijckmans; D. Leysen; K. Audenaert; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB 👁 1 views

## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)