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Synthesis and radiation-protection and antihypoxia properties of 3-hydroxypiperidin-4-one derivatives

✍ Scribed by T. Yu. Il'yuchenok; M. N. Romanchak; I. G. Tishchenko; L. S. Stanishevskii; L. M. Frigidova; Yu. V. Zav'yalov; K. S. Shadurskii; A. S. Zakharevskii; A. V. Miklevich

Book ID
112408003
Publisher
Springer
Year
1978
Tongue
English
Weight
284 KB
Volume
12
Category
Article
ISSN
0091-150X

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A new synthesis of alkaloid (S)-3-hydrox
A new synthesis of alkaloid (S)-3-hydroxypiperidin-2-one and its O-TBS protected derivative
✍ Pei-Qiang Huang; Guo Chen; Xiao Zheng πŸ“‚ Article πŸ“… 2007 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 253 KB

## Abstract magnified image From the known lactone (__S__)‐**4**, easily derived from L‐glutamic acid, a scalable approach to chiral building block __O__‐silylated 3‐hydroxypiperidin‐2‐one **3** and alkaloid **1** was achieved in five and six‐steps respectively. The key steps are a chemoselective