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Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates

✍ Scribed by Mor, Marco; Lodola, Alessio; Rivara, Silvia; Vacondio, Federica; Duranti, Andrea; Tontini, Andrea; Sanchini, Silvano; Piersanti, Giovanni; Clapper, Jason R.; King, Alvin R.; Tarzia, Giorgio; Piomelli, Daniele


Book ID
127344025
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
884 KB
Volume
51
Category
Article
ISSN
0022-2623

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Quantitative structure–activity relation
✍ Peng Lu; Ruisheng Zhang; Yongna Yuan; Zhiguo Gong 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB 👁 2 views

## Abstract A quantitative structure activity relationship (QSAR) analysis was performed on the $K\_i $ values of a series of fatty acid amide hydrolase (FAAH) inhibitors. Six molecular descriptors selected by CODESSA software were used as inputs to perform heuristic method (HM) and support vector