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Synthesis and Pummerer reaction of 2-F-alkyl-2-hydroxyethylphenyl sulfoxides

✍ Scribed by Ahmed Hedhli; Stéphane Szönyi; Ahmed Baklouti; Aimé Cambon


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
675 KB
Volume
69
Category
Article
ISSN
0022-1139

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a-Lithiated 1-[(2-methoxyethoxy)methoxy]-2-(phenylsylfinyl)cyclopropane reacted smoothly with alkylating agents to afford the corresponding a-alkylated cyclopropylsulfoxides, which underwent the Pummerer-type reaction mediated ring-opening at low temperature (-78°C) by employing TFAA/Pr i 2 NEt/CH 2