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Synthesis and Properties of Some Spin Labeled Uridine and 2′-Deoxyuridine Analogues

✍ Scribed by Alvydas J. Ozinskas; Albert M. Bobst


Publisher
John Wiley and Sons
Year
1979
Tongue
German
Weight
272 KB
Volume
62
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The synthesis of the spin‐labeled uridine and 2′‐deoxyridine analogues RUGT 2, DUGT 3, l‐RUGT 4, and l‐DUGT 5 is described. DUGT 3 showed some activity against the leukemia P388 cell line.


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Synthesis and Biological Activities of C
✍ Albert M. Bobst; Alvydas J. Ozinskas; Erik De Clercq 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 German ⚖ 422 KB 👁 1 views

## Abstract Direct introduction of a N‐atom in one step at C (5) of 5‐hydroxyuridine **(4a)** or 5‐hydroxy‐2′‐deoxyuridine **(4b)** by certain primary amines led to the synthesis of two novel C(5)‐N‐spin‐labeled nucleoside analogs and to several C(5)‐N‐aryl adducts. Substitution by 4‐amino‐2,2,6,6‐