Synthesis and properties of some derivatives of 2-thionoindeno [1,2-d]-pyrimidine and indeno [1,2-d] [3,1] thiazine

✍ Scribed by A. Z. Zandersons; V. K. Lusis; é. é. Liepin'sh; D. Kh. Mutsenietse; E. L. Khanina; G. Ya. Dubur

• Book ID: 104783041
• Publisher: Springer US
• Year: 1988
• Tongue: English
• Weight: 502 KB
• Volume: 24
• Category: Article
• ISSN: 0009-3122
• DOI: 10.1007/bf00479354

✦ Synopsis

with chloroform (three 100-ml portions). The extract was dried with sodium sulfate, the solvent was evaporated, and the residue was chromatographed in chloroform. The characteristics of X/fV and XXVII-XXIX are presented in Tables 345. 8,9;17,13,16-triazacvclooctadecane (XXVI) A 5.0-g (0.217

mole) sample of sodium was added in the course of 2 h to a heated (to 100~ solution of 3.82 g (7.47 mmole) of XXI in i00 ml of n-butyl alcohol. After the sodium had dissolved completely, the solution was cooled and washed with water (three 100-ml portions), and 120 ml of 20% HCI solution was added to the butanol layer. After prolonged shaking, the butanol layer was separated and discarded, and the aqueous layer was made alkalinewith 30%KOH solution to pH ~ 12 and cooled. The precipitate was separated, washed with 200 ml of water, and dried in vacuo to give 1.78 g (67%) of product. The characteristics are presented in Tables 345.