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Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines
✍ Scribed by Raid J. Abdel-Jalil; Raed A. Al-Qawasmeh; Wolfgang Voelter; Peter Heeg; Mustafa M. El-Abadelah; Salim S. Sabri
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 182 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
The 2,3‐disubstituted 6‐fluoro‐7‐(4‐methyl‐1‐piperazinyl)‐quinoxalines (3–11) were synthesized for bioassay via reaction of 1.2‐diamino‐4‐fluoro‐5‐(4‐methyl‐1‐piperazinyl)benzene (2) with the appropriate 1,2‐dicarbonyl compounds. However, none of the tested compounds 3–11 showed significant in vitro activ ity against E. coli ATCC11229, S. aureus ATCC6538 and C.albicans SATCC10231.
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## Abstract magnified image A series of new unsymmetrical 3‐phenyl‐6‐benzyl‐1,2,4,5‐tetrazine derivatives **10a‐i** were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of **4a, 10c, 10d** and **10h** were analyzed by X‐ray crystallography, which had intermolecul