## Abstract We studied the effects of 13‐cis‐retinoic acid (13cRA) and 4‐hydroxyphenyl‐all‐trans‐retinamide (4HPR) on the proliferation of clonogenic human tumor colony‐forming units (TCFU) from patient biopsies in soft agar. Continuous exposure (5 × 10^−6^M) to 13cRA and 4HPR reduced colony format
Synthesis and properties of some 13-cis and all-trans-retinamides
✍ Scribed by Y. Fulmer Shealy; Jerry L. Frye; C. Allen O'Dell; Martha C. Thorpe; Marion C. Kirk; W. C. Coburn Jr; Michael B. Sporn
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 1018 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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A method employing trifluoroacetic acid for the quantitative determination ofallrrans-retinoic acid and 13-cis-retinoic acid in serum is described. The method permits the detection of as little as 0.3 Kg of either compound. Retinoic acid can serve the general tissue functions of vitamin A, except i
## Abstract The capillary gas chromatographic (CGC) analysis of the der‐matological drug __trans__‐acitretin (Neotigason^R^) and its __cis__ metabolite is described. Separation of the methyl ester derivatives can be achieved on a 90% biscyanopropylsiloxane phase. The importance of using cold on‐col