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Synthesis and properties of oligodeoxyribonucleotides containing 2’-O-(2,3-dihydroxypropyl)- and 2’-O-(2-oxoethyl)arabinouridine residues

✍ Scribed by T. S. Zatsepin; Yu. M. Ivanova; D. A. Stetsenko; M. J. Gait; T. S. Oretskaya

Book ID
106519597
Publisher
Springer
Year
2005
Tongue
English
Weight
417 KB
Volume
54
Category
Article
ISSN
1573-9171

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✍ Marija Prhavc; Elena A Lesnik; V Mohan; Muthiah Manoharan 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 115 KB

In order to evaluate the effect of a new 2%-carbohydrate modification on the hybridization properties of oligonucleotides, uridine 2%-O-carbamates were synthesized and incorporated into DNA strands. The key intermediate in the synthesis, a mixed succinimide carbonate 2, was treated with various amin