Synthesis of 5-(functionalized acyl)-1,3
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Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski
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Article
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2001
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Journal of Heterocyclic Chemistry
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English
β 53 KB
## Abstract A sodium derivative of 1,3βdimefhylbarbituric acid or 1,3βdiethylβ2βthiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with Οβchloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor