Synthesis and properties of 1,2-diaryl-4,5,6,7-tetrahydro-1H-1,3-diazepines and 1,2-diaryl-1,4,5,6,7,8-hexahydro-1,3-diazocines. Comparison with the five- and six-membered homologues
✍ Scribed by Perillo, Isabel; Fern�ndez, Beatriz; Lamdan, Samuel
- Book ID
- 127298745
- Publisher
- Royal Society of Chemistry
- Year
- 1977
- Tongue
- English
- Weight
- 589 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1472-779X
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## Abstract The synthesis of several 1,2‐diaryl‐1__H__‐4,5,6,7‐tetrahydro‐1,3‐diazepines **1** by cyclization of __N__‐aryl‐__N'‐__benzoyltetramethylenediamines **2** is described. Two alternative synthetic routes to obtain precursors **2** are discussed, being that which employes pyrrolidine as st
## Abstract Basicity and alkaline hydrolysis of 1,2‐diaryl‐1__H__‐4,5,6,7‐tetrahydro‐1,3‐diazepines 1 are studied. Results are analyzed on the basis of Hammett and Swain‐Lupton constants, finding good structure‐basicity correlation when both, inductive and mesomeric effects, are considered together
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