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Synthesis and properties of 1-(3-(fluoromethyl and trifluoromethyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives

✍ Scribed by Vytautas Mickevičius; Rita Vaickelionienė; Ilona Jonuškienė; Gema Mikulskienė; Kristina Kantminienė

Publisher
Springer Vienna
Year
2009
Tongue
English
Weight
323 KB
Volume
140
Category
Article
ISSN
0026-9247

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✍ James W. Pavlik; Jennifer A. Lowell; Vuthichai Ervithayasuporn 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 65 KB

Reaction of 4,4,4-trifluoro-1-phenyl-1,3-butanedione with hydroxylamine led to the formation of 5hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole which was dehydrated to 3-phenyl-5-(trifluoromethyl)isoxazole. This isomer can also be synthesized by reaction of 4-chloro-4-phenyl-1,1,1-trifluo