Synthesis and processing of lysosomal α-fucosidase in cultured human fibroblasts
✍ Scribed by Johnson, Karl F.; Hancock, Larry W.; Dawson, Glyn
- Book ID
- 122797572
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 565 KB
- Volume
- 1073
- Category
- Article
- ISSN
- 0304-4165
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Human a-L-fucosidase, purified from placenta, was taken up from the culture medium by skin fibroblasts from patients with fucosidosis (a-L-fucosidase deficiency). The rate of uptake was low (uptake coefficient = 6 x lo-\* ml.mg-l.h-\*). Intracellular a-L-fucosidase activity was directly proportiona