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Synthesis and preliminary pharmacology of 2-aminophenol derivatives

โœ Scribed by Donald R. Mileski; Harvey R. Kaplan; Marvin H. Malone; Karl A. Nieforth


Book ID
102396218
Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
414 KB
Volume
54
Category
Article
ISSN
0022-3549

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โœฆ Synopsis


A number of 2-aminophenol derivatives have been prepared which, upon gross pharmacologic screening, were found to stimulate the central nervous system, while several compounds exhibited possible psychosomimetic activity.


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## Abstract Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were synthesised from chalcone-like intermediate and substituted phenyl hydrazines, hydrazine hydrate, and semi/thiosemicarbazide. The chemical structure of compounds was confirmed by means of IR