✦ LIBER ✦

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

✍ Scribed by Hakan Göker; Mehmet Alp; Zeynep Ateş-Alagöz; Sulhiye Yıldız

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 186 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.179

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

A series of 47 novel N^1^‐alkylated‐2‐aryl‐5(6)‐substituted‐1__H__‐benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C‐2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25–3.12 μg/mL. Indole analogues 108‐110 have no inhibitory activity. J. Heterocyclic Chem., (2009).

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Poten

ChemInform Abstract: Synthesis and Potent Antifungal Activity Against Candida Species of Some Novel 1H-Benzimidazoles.

✍ Hakan Goeker; Mehmet Alp; Zeynep Ates-Alagoez; Sulhiye Yildiz 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Novel Endoperoxides: Synthesis and Activ

Novel Endoperoxides: Synthesis and Activity Against Candida Species.

✍ Peter Macreadie; Thomas Avery; Ben Greatrex; Dennis Taylor; Ian Macreadie 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 23 KB

Synthesis of Some 1-(2,4-Dihydroxythiobe

Synthesis of Some 1-(2,4-Dihydroxythiobenzoyl)imidazoles, -imidazolines and -tetrazoles and their Potent Activity Against Candida Species.

✍ Joanna Matysiak; Andrzej Niewiadomy; Elzbieta Krajewska-Kulak; Grazyna Macik-Nie 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 104 KB 👁 1 views

Synthesis and Potent Antibacterial Activ

Synthesis and Potent Antibacterial Activity Against MRSA of Some Novel 1,2-Disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines.

✍ Hakan Goeker; Seckin Oezden; Sulhiye Yildiz; David W. Boykin 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

Novel Antifungal β-Amino Acids: Synthesi

Novel Antifungal β-Amino Acids: Synthesis and Activity Against Candida albicans.

✍ Joachim Mittendorf; Franz Kunisch; Michael Matzke; Hans-Christian Militzer; Axel 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 20 KB

Antifungal activity of DNA–lipid complex

Antifungal activity of DNA–lipid complexes and DNA–lipid films against Candida species

✍ Y. Inoue; T. Fukushima; T. Hayakawa; R. Ogura; H. Kaminishi; K. Miyazaki; Y. Oka 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 220 KB

## Abstract In this study amphiphilic lipids, DNA–lipid complexes, and DNA–lipid films were prepared, and their antifungal activity against __Candida__ species was examined. The amphiphilic lipids were synthesized from a reaction of glycine or L‐alanine with __n__‐alkyl alcohol in the presence of _