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Synthesis and plasma pharmacokinetics in CD-1 mice of a 18β-glycyrrhetinic acid derivative displaying anti-cancer activity

✍ Scribed by Lallemand, Benjamin; Ouedraogo, Moustapha; Wauthoz, Nathalie; Lamkami, Touria; Mathieu, Veronique; Jabin, Ivan; Amighi, Karim; Kiss, Robert; Dubois, Jacques; Goole, Jonathan

Book ID
119876969
Publisher
Pharmaceutical Press
Year
2012
Tongue
English
Weight
555 KB
Volume
65
Category
Article
ISSN
2042-7158

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## Abstract Methyl 2‐cyano‐3,11‐dioxo‐18β‐olean‐1,12‐dien‐30‐oate (CDODA‐Me) is a synthetic triterpenoid derived from glycyrrhetinic acid, a bioactive phytochemical in licorice, CDODA‐Me inhibits growth of Panc1 and Panc28 pancreatic cancer cell lines and activates peroxisome proliferator‐activated